Efficacy and Safety of Ayurvedic Formulations in the Management of Dyslipidaemia: A Pilot Clinical Trial

Abstract

Dyslipidaemia (Medoroga) is a metabolic disorder associated with vitiation of Kaphadosha and Medadhatu, commonly linked with obesity and sedentary lifestyle. Ayurvedic management aims to correct Agnimandya and reduce lipid imbalance. To evaluate the efficacy and safety of Ayurvedic treatment in improving lipid profile and clinical symptoms in dyslipidaemiapatients. A total of 30 patients (18 males, 12 females), mainly aged 41–50 years and overweight/obese, were enrolled. The intervention was administered for 12 weeks. Lipid profile and clinical symptoms were assessed at baseline, 6th week, and 12th week. Safety parameters including liver and kidney function tests were also monitored.Significant improvement was observed in lipid parameters. Total cholesterol reduced from 244.8 ± 16.2 to 196.3 ± 13.5 mg/dL (p < 0.001), LDL from 158.6 ± 13.4 to 118.4 ± 11.2 mg/dL (p < 0.001), and triglycerides from 208.4 ± 18.6 to 162.7 ± 15.4 mg/dL (p < 0.001). HDL increased from 39.2 ± 4.8 to 46.1 ± 4.2 mg/dL (p < 0.01). Clinical symptoms such as Gaurava, Alasya, and Swedadhikya showed marked reduction. No significant adverse effects were observed SGOT, SGPT, and serum creatinine remained stable. Overall, 12 patients showed marked improvement, 11 moderate, and 7 mild improvement. Ayurvedic intervention demonstrated significant lipid-lowering and symptom-relieving effects without adverse events. The results suggest effective management of Medoroga through correction of Agnimandya,Ama formation, and Kapha–Meda imbalance using Lekhana and Medoharaprinciples.