Formulation and evaluation of Gliclazide loaded nanoparticles for management of diabetes

Abstract

Diabetes mellitus (DM) is widely escalating chronic disease and most common in elder person. Gliclazide nanoparticles (GCZNPs) were prepared using solvent evaporation technique. Prepared nanoparticles were characterized for particle size, drug entrapment, in vitro drug release. The compatibility between drug and excipients was examined by Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC). The particle size of prepared GCZNPs was found to be in ranged from 295.5 to 720.04 nm. The drug entrapment efficiency of GCZNPs was in range 50.67 to 79.16 %. The percentage of drug loading was found 14.1 to 36.78. The optimized formulation, PLA 50 and PVA 0.45, 36.885 % of drug loading, resulted in 78.630 % of entrapment efficiency, particle size of 277.04 nm and released 75.43 % in 10 hrs. Conclusively, solid lipid nanoparticles of GCZ were successfully formulated with higher drug entrapment and could serve as promising delivery for poorly soluble drug.