DEVELOPMENT AND IN-VITRO STUDY OF BPNF IN DIABETIC WOUND

Abstract

Diabetic wounds are difficult to heal due to poor blood circulation and delayed tissue regeneration. The present study focuses on the development of Biopolymeric Nanofiber (BPNF) for enhanced diabetic wound healing. BPNF was prepared using electrospinning technique by combining biocompatible polymers and therapeutic agents with antioxidant and antimicrobial activity. The prepared nanofiber was evaluated for its morphology, drug release, and cytocompatibility. Results showed that the optimized BPNF had uniform fibers, sustained drug release, and excellent cell compatibility. It also promoted fibroblast proliferation and migration, suggesting faster wound healing. Hence, the developed BPNF could be a promising nanofibrous dressing for effective management of diabetic wounds.