Evaluation Of Subgingival Fusobacterium Nucleatum Levels After Srp With Adjunctive Aloe Vera As Ldd In Chronic Periodontitis – A Randomized Controlled Trial

Abstract

Context: Periodontitis is the inflammatory disease results from the interaction between microorganisms and immune response in a susceptible host. Porphyromonas gingivalis, Tanerella forsythia, Treponema denticola, Fusobacterium nucleatum are most notorious organisms implicated in destruction of periodontal tissues. Scaling and Root planing (SRP) is considered as “Gold Standard” initial treatment of periodontitis. As an adjunct to SRP, Naturopathic medicines as Local drug delivery (LDD) system has become an effective treatment option. Aloe Vera species is extensively used in Periodontology as LDD due to its easy availability and innumerable medicinal properties with minimal or no adverse effects.

Aims: To Compare Subgingival Fusobacterium nucleatum levels and Clinical parameters after SRP with Adjunctive Aloe vera as LDD in Chronic Periodontitis patients. Settings and Design: A Split Mouth, Double Blind, Randomized Controlled Trial.

Methods and Material: 35 subjects were randomized to test (SRP with Aloe vera gel) and control group (SRP alone). Clinical parameters (PPD, CAL, GBI and PI) were recorded and plaque samples were collected for F. nucleatum assessment. All subjects received SRP and test group alone received subgingival delivery of 0.5ml Aloe vera gel. Parameters were reassessed at 1 and 3 months.

Statistical analysis used: Mann Whitney U test, T test & Repeated measures ANOVA. Results: Post-Op 3-months RT-PCR showed statistically significant values (p-value=0.01*) between both groups from baseline till 3 months.

Conclusion: Since Aloe vera gel reduces levels of F. nucleatum and improves clinical parameters, it can be used as LDD.