Formulation and Evaluation of Solid Lipid Nanoparticles of Ramipril

Abstract

This work aims to enhance the bioavailability and manage the release of ramipril, an antihypertensive medication that is weakly water-soluble, by developing and evaluating solid lipid nanoparticles (SLNs) for its delivery. Different SLN formulations were tested for their effects on drug release kinetics and particle size distribution. The formulations included surfactants PF-68, T-80, and S-20, as well as lipid matrices GMS and GMO. After 12 hours of in vitro drug release testing, the formulations showed cumulative drug release ranging from 52% to 83%. GMS matrix the formulations containing S-20 surfactant showed the lowest particle size of 108 nm were generally found to release the drug optimally (82%-83%). On the contrary, some of the largest particles were GMO and T-80 exhibiting the slowest rate of drug release. The findings further indicate that SLNs could significantly enhance the dissolution and bioavailability of ramipril with a controlled and sustained release, thus qualifying as a promising delivery system for poorly soluble drugs.