Urinary enzymes as early diagnostic marker for cisplatin induced renal damage : a comparison with Cystatin C
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Abstract
Background. Serum cystatin C have been proposed to be early diagnostic marker for cisplatin induced renal injury, but it is not widely available. Urinary enzymes which are markers of tubular damage viz. urinary GGT/ALP/LDH and their creatinine standardized ratio can serve as early diagnostic markers for renal tubular damage as seen in cisplatin induced renal injury.
Methods. Serum and urine samples were taken from 30 cancer patients on Day 1 Day 3 Day 7 after cisplatin first dose. Determination of serum creatinine, cystatin c and urinary ALP, LDH and GGT creatinie ratio was done .
Results. Standardised GGT,ALP,LDH and serum creatinine was significantly higher at day 3 and day 7 compared to day 1 (p < 0.0001) also on day 7 was significantly higher compared to day 3 (p < 0.0001). Cystatin C was significantly higher at day 3 and day 7 compared to day 1 (p < 0.05) also on day 7 was significantly higher compared to day 3 (p < 0.05).
Conclusions. Urinary GGT, ALP and LDH creatinine standardised ratio and serum cystatin C are early diagnostic maker for cisplatin induced renal injury but GGT and ALP have better diagnostic importance on day 3 and day 7 respectively.